Nuclear mA Reader YTHDC1 Regulates mRNA Splicing

Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing.

N(6)-Methyladenosine (m(6)A) is emerging as a chemical mark that broadly affects the flow of genetic information in various biological processes in eukaryotes. Recently, Xiao et al. reported that the nuclear m(6)A reader protein YTHDC1 impacts mRNA splicing, providing a transcriptome-wide glance of splicing changes affected by this mRNA methylation reader protein.

New Edges of RNA Adenosine Methylation Modifications

Recently an article published in Molecular Cell reveals the mechanism of a nuclear N-methyladenosine (mA) reader, the YTH domain-containing protein 1 (YTHDC1), in regulating pre-mRNA splicing [1]. Meanwhile, two additional articles published in Nature and Nature Chemical Biology report the first transcriptome-wide maps of N-methyladenosine (mA) at high resolution, suggesting a functional role f...

YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs

N6-methyladenosine (m6A) is the most abundant internal modification of eukaryotic messenger RNA (mRNA) and plays critical roles in RNA biology. The function of this modification is mediated by m6A-selective 'reader' proteins of the YTH family, which incorporate m6A-modified mRNAs into pathways of RNA metabolism. Here, we show that the m6A-binding protein YTHDC1 mediates export of methylated mRN...

TITLE : C 3 G dynamically associates with Nuclear speckles and regulates mRNA splicing RUNNING HEAD : C 3 G regulates splicing AUTHORS : Dhruv

The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn).

Alternative pre-mRNA splicing patterns can change an extracellular stimulus, but the signaling pathways leading to these changes are still poorly characterized. Here, we describe a tyrosine-phosphorylated nuclear protein, YT521-B, and show that it interacts with the nuclear transcriptosomal component scaffold attachment factor B, and the 68-kDa Src substrate associated during mitosis, Sam68. No...